International Research and Academic scholar society

IRASS Journal of Applied Medical and Pharmaceutical Sciences

Issue-2(February), Volume-3 2026

1. Effect of Zingiber Officinale Ethanol Extract on Renal Functions of Ma...
5

Cyril Onyekachi Edoga*, Ezema,...
Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology (ESUT), Enugu Nigeria
1-6
https://doi.org/10.5281/zenodo.18798143

This study evaluated the effect of ethanol extract of Zingiber officinale on renal function markers in male Wistar albino rats subjected to albumin-induced inflammation. The animals were divided into five groups: blank control, negative control (inflammation without treatment), standard control (treated with a reference anti-inflammatory drug), and two treatment groups administered low and high doses of Z. officinale extract. Renal function was assessed through serum creatinine, urea, calcium (Ca), and chloride (Cl⁻) levels. The negative control group exhibited significantly elevated levels of creatinine (0.59±0.00 mg/dl), urea (12.22±0.001 mg/dl), and calcium (6.93±0.11 ppm), alongside a sharp reduction in chloride (4.42±0.00 ppm), compared to the blank control (p < 0.05), indicating renal impairment caused by inflammation. Treatment with high-dose Z. officinale extract significantly restored creatinine (0.52±0.00 mg/dl), urea (11.02±0.03 mg/dl), calcium (5.33±0.13 ppm), and chloride (7.54±0.11 ppm) levels to values comparable to the standard control and blank groups (p > 0.05), while the low-dose treatment showed only partial improvement. These findings demonstrate that Zingiber officinale ethanol extract, particularly at high doses, possesses nephroprotective properties, mitigating inflammation-induced renal dysfunction and restoring electrolyte balance.

2. Effect of Zingiber Officinale Ethanol Extract on Reproductive Hormones...
2

Cyril Onyekachi Edoga*, Okoh,...
Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology (ESUT), Enugu Nigeria
7-11
https://doi.org/10.5281/zenodo.18798260

Reproductive function is known to be disrupted by inflammation, and Zingiber officinale, has long been used to treat inflammatory diseases. In this work, male albino Wistar rats with albumin-induced inflammation were used to assess the modulatory effects of Zingiber officinale ethanol extract on reproductive hormones, such as testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). A control group, an inflammation-induced group, and groups treated with different dosages of Zingiber officinale ethanol extract comprised the five (5) groups of thirty (30) male albino Wistar rats. Albumin was used to cause inflammation, and the extract was taken orally for three weeks. Standard laboratory methods, such as enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA), were used to evaluate hormone levels. The results showed that Zingiber officinale ethanol extract significantly modulated reproductive hormone levels in the treated groups compared to the control groups. Specifically, testosterone levels increased (14.39 ± 0.0003), while FSH and LH levels showed dose-dependent responses. The findings suggest that Zingiber officinale ethanol extract may have a regulatory effect on reproductive hormone production in male albino Wistar rats with albumin-induced inflammation, potentially due to its anti-inflammatory and antioxidant properties. These results have potential implications for the treatment of reproductive disorders associated with inflammation and warrant further investigation into the mechanisms underlying the modulatory effects of Zingiber officinale on reproductive hormones.





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